Faculty Profile


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Kelly S. Doran

Assistant Professor
University of California San Diego (1998)
Department of Biology
Cell & Molecular Doctoral Program
Molecular Biology Masterís Program

619 594-1867

Email 
kdoran@mail.sdsu.edu


The overall interest of the lab is the study of bacterial pathogens associated with Central Nervous System disease. We examine the mechanisms by which bacteria penetrate the blood-brain barrier, in order to cause meningitis. Our studies focus on major human pathogens including Streptococcus, Staphylococcus aureus and Bacillus anthracis. We seek to identify bacterial genes and gene products responsible for cellular invasion, and to characterize the host innate immune response to infection.

Lab website

Selected Publications:

 

Banerjee, A., Kim, B. J., Carmona, E.M., Cutting, A.S., Gurney, M.A., Carlos, C., Feuer, R., Prasadarao, N.V, and Doran, K.S.  2011. Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration. Nature Communications. Sept 6, DOI: 10:1038/ncomms1474.

Ebrahimi, C.M., Sheen, T.R., Renken, C.W., Gottlieb, R.A., and Doran, K.S. 2011. Contribution of lethal toxin and edema toxin to the pathogenesis of anthrax meningitis. Infect. Immun. 79(7): 2510-2518.

van Sorge, N.M, Zialcita, P., Browne, S.H., Quach D, Guiney, D., and Doran, K.S. 2011. Penetration and activation of brain endothelium by Salmonella enterica serovar Typhimurium. J. Infect. Dis. 203(3): 401-405.

Banerjee, A., van Sorge, N.M., Sheen, T.R., Uchiyama S, Mitchell TJ, and Doran, K.S.  2010. Activation of brain endothelium by pneumococcal neuraminidase NanA promotes bacterial internalization. Cellular Microbiol. 12(11): 1576-1588.

Lembo, A., Gurney, M.A., Burnside, K., Banerjee, A., de Los Reyes, M., Connelly, J.E., Lin, W.J., Jewell, K.A., Vo, A., Renken, C.W., *Rajagopal. L., *Doran, K.S. (*co-corresponding authors). 2010. Regulation of CovR expression in Group B streptococcus impacts blood-brain barrier penetration. Mol. Microbiol. 77(2): 431-443.

Sheen, T.R., Ebrahimi, C.M., Heimstra, I.H.,  Barlow, S. B., Peschel, A., and Doran, K.S. 2010. Penetration of the blood-brain barrier by Staphylococcus aureus: Contribution of membrane-anchored lipoteichoic acid. J. Mol. Med. 88(6) 633-639.

Ebrahimi, C.M., Kern, J.W., Sheen, T.R., Ebrahimi-Fardooee, M.A., van Sorge, N.M., Schneewind, O., and Doran, K.S. 2009. Penetration of the blood-brain barrier by Bacillus anthracis requires the pXO1-encoded BslA protein. J. Bacteriol. Dec; 191(23): 7165-7173.

Uchiyama S, Carlin AF, Khosravi A, Weiman, S, Banerjee, A, Quach D, Hightower G, Mitchell TJ, Doran, K.S. and Nizet, V. 2009. The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion. J. Exp. Med. 206 (9): 1845-1852.

van Sorge, N.M., Quach, D, Gurney, M.A., Sullam, P.M., Nizet V. and  Doran, K.S. 2009. The group B streptococcal Srr-1 glycoprotein mediates penetration of the blood-brain barrier. J. Infect. Dis. 199 (10): 1479-1487. (featured on cover)

Quach, D, van Sorge, N.M., Kristin, S., Bryan, J., Shelver, D.W. and  Doran, K.S. 2009. The CiaR response regulator in group B streptococcus promotes intracellular survival and resistance to innate immune defenses. J. Bacteriol. 191(7): 2023-32.

van Sorge, N.M., Quach, D, Gurney, M.A., Sullam, P.M., Nizet V. and  Doran, K.S. 2009. The group B streptococcal Srr-1 glycoprotein mediates penetration of the blood-brain barrier. J. Infect. Dis. 199 (10): 1479-1487. (featured on cover)

 

Quach, D, van Sorge, N.M., Kristin, S., Bryan, J., Shelver, D.W. and  Doran, K.S. 2009. The CiaR response regulator in group B streptococcus promotes intracellular survival and resistance to innate immune defenses. J. Bacteriol. 191(7): 2023-32. (Epub 2008 Dec 29)

 
van Sorge, N.M., Ebrahimi, C., McGillivray, S., Quach, D, Sabet, M., Guiney, D., and Doran, K.S. 2008. Anthrax toxins inhibit neutrophil signaling pathways in brain endothelium and contribute to the pathogenesis of meningitis. PLoSONE. 3(8): 2964.

van Sorge, N.M., Ebrahimi, C., McGillivray, S., Quach, D, Sabet, M., Guiney, D., and Doran, K.S. 2008. Anthrax toxins inhibit neutrophil signaling pathways in brain endothelium and contribute to the pathogenesis of meningitis. PLoSONE. 3(8): 2964.

 

Maisey HC, Quach D, Hensler ME, Liu GY, Nizet V. and  Doran, K.S. 2008. A group B streptococcal pilus protein promotes virulence and phagocyte resistance. FASEB J. 6: 1715-1724.

 

Doran, K.S., Engelson, E.J., Khosravi, A., Maisey, H.C., Fedtke, I., Equils, O., Michelsen, K.S., Arditi, M., Peschel, A., and Nizet, V. 2005. Blood-brain barrier invasion by group B streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid. J. Clin. Invest. 115: 2499-2507.

 

Liu, G.Y., Doran, K.S., Lawrence, T., Turkson, N., Puliti, M., Tissi, L., Nizet, V. 2004.  Sword and shield: linked group B streptococcal B-hemolysin/cytolysin and carotenoid pigment act synergistically to subvert phagocytic defenses. Proc. Natl. Acad. Sci. 101: 14491-14496.

 

Doran, K.S. and Nizet, V. 2004. Molecular pathogenesis of neonatal group B streptococcal infection: no longer in its infancy. Mol. Microbiol. 54: 23-31.

 

Doran, K.S., Liu, G.Y., Nizet, V. 2003. Group B streptococcal B-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis. J. Clin. Invest. 112: 736-744.

 

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